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Dr. Ken Murphy obtained his MD and PhD from the Johns Hopkins University School of Medicine. In 1984, he began a residency in Pathology at Washington University School of Medicine in St. Louis. After this, he did postdoctoral work in molecular immunology with Dr. Dennis Loh, where he generated the DO11.10 TCR transgenic mouse used in studies of self-tolerance, and later in studies of Th1/Th2 development. In 1990, he joined the Pathology and Immunology Department at Washington University, where he is now full professor and an investigator of the Howard Hughes Medical Institute. His work has focused on important cell fate and lineage decisions during the development of the immune system and during immune responses to pathogens, particularly at the transcriptional level. His lab was the first to demonstrate that the innate immune system, through interactions with pathogens, controls the quality of the adaptive immune response, such as induction of Th1 development through macrophage- and dendritic cell-derived cytokines. Current work continues to focus on important fate decisions, such as the development of specialized subsets of dendritic cells involved in the activation of T cell responses to viral pathogens.
Ken Murphy, PhD, Eugene Opie First Centennial Professor of Pathology & Immunology, Washington University School of Medicine