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Single cell analysis of the effector T cell transcriptome

Air date: Wednesday, January 17, 2018, 4:15:00 PM
Time displayed is Eastern Time, Washington DC Local
Description: Immunonology IG Seminar

Dr. Thomas Ciucci is a post-doctoral fellow in Dr. Rémy Bosselut’s group within the Laboratory of Immune Cell Biology (LICB). He received a Ph.D. in Genetics and Immunology from the University of Nice, France in 2012. His doctoral research work investigated the relationship between inflammatory immune cells, the tumor environment and bone tissue. Dr. Ciucci joined Dr. Bosselut’s group in 2013 to pursue his interests in the regulation of T cell responses. His research has focused on two aspects of T cell differentiation during the immune response. The first, identified a previously unrecognized feature of T cell responses to distinct classes of pathogens. Specifically, Dr. Ciucci showed that a transcriptional circuitry of IL-17-producing T cells, characteristic of the response to extra-cellular pathogens and driven by STAT3, represses the expression of genes involved in cytotoxicity, a function critical to T cell-mediated killing. In more recent work, Dr. Ciucci pioneered the use of single-cell RNAseq to investigate the transcriptome of anti-viral effector and memory T cells. These studies led him to identify a novel transcriptional check-point controlling the emergence of memory CD4+ T cells during the early phase of the immune response. Together, his work, redefines how gene expression acts to orchestrate protective immune response against pathogens and sheds light on the transcriptional circuitry involved during dysfunctional immune response to chronic infections and cancer.
Author: Thomas Ciucci, PH.D., Laboratory of Immune Cell Biology, NCI, NIH
Runtime: 1 hour