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The IL-23-Th17 Immune Axis: From Bench to Bedside

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Air date: Wednesday, October 11, 2017, 4:15:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 206, (86 Live, 120 On-demand)
Category: Immunology
Runtime: 01:04:58
Description: Immunonology Interest Group Seminar

Following the discovery of IL-23-dependent T cell immunity, the past decade has witnessed a major revision of the T-helper subset paradigm and substantial progress has been made in deciphering the molecular mechanisms of T cell lineage commitment and function. Our recent work focused on the transcriptional control of Th17 cell development, as well as the protective versus pathogenic roles of IL-17 and IL-22 in mucosal tissues. I will discuss the concept of immune ‘counter-regulation’ during organ-specific tissue inflammation. I will also highlight recent clinical data demonstrating that neutralization of IL-17 and IL-23 are remarkably effective for treating immune-mediated inflammatory diseases.
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Author: Dan Cua, Ph.D., Senior Principal Scientist, Immuno-Oncology Discovery, Merck
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CIT Live ID: 23454
Permanent link: https://videocast.nih.gov/launch.asp?23509