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Myeloid-derived Trefoil Factor 2 (TFF2) controls epithelial regeneration at the mucosal interface (NIH Only)

   
Air date: Wednesday, November 1, 2017, 4:15:00 PM
Time displayed is Eastern Time, Washington DC Local
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Description: Immunology Interest Group Seminar Series

Trefoil factor proteins, an enigmatic family of mucosal cytokines, are known to promote tissue repair. Despite being discovered decades ago, not much was known until recently about how Trefoil proteins work. Dr. Herbert’s laboratory has discovered that these proteins regulate immune responses in allergic asthma and hookworm infection, and that they trigger the regeneration of epithelial cells.

De’Broski Herbert is an Associate Professor of Immunology at the University of Pennsylvania School of Veterinary Medicine. He received his B.S. in microbiology from Xavier University in New Orleans, and his Ph.D. in immunology from Thomas Jefferson University in Philadelphia. De’Broski received a Colin Powell Tropical Disease Postdoctoral Fellowship to research infectious immunology at the University of Cape Town in South Africa. In 2007, he received his first NIH-RO1 and became a tenure track faculty member at the University of Cincinnati/Cincinnati Children’s Hospital starting in 2009. He was recruited to the University of California at San Francisco in 2012 where he was promoted to the rank of Associate Professor. He relocated his lab to UPenn in 2016. De’Broski has made numerous important contributions to our understanding of the regulatory networks that control immunity, inflammation, and tissue repair at mucosal surfaces. He has characterized roles for intestinal epithelia in driving type 2 host immunity against gastrointestinal worms and for alternatively activated macrophages in regulating intestinal immunopathology.
Author: De’Broski Herbert, Ph.D., Associate Professor of Immunology, University of Pennsylvania School of Veterinary Medicine
Runtime: 1 hour