NIH VideoCast - Coupling Single-Cell RNA-seq with Tracking of Regulatory Determinants Reveals Rare Hematopoietic Transition States

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Coupling Single-Cell RNA-seq with Tracking of Regulatory Determinants Reveals Rare Hematopoietic Transition States

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Air date:	Wednesday, December 16, 2015, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 274 (43 Live, 231 On-demand)
Category:	Immunology
Runtime:	00:53:27
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Immunology Interest Group Dr. Grimes received his Ph.D. in Molecular Pathology and Immunology studying gene regulation with Maureen Goodenow at the University of Florida, then joined Philip Tsichlis at Fox Chase Cancer Center, cloning novel genes activated by insertion mutagenesis (e.g. Akt, Tpl2). He has a broad background in hematopoiesis, molecular biology, and molecular oncology including modeling of hematopoiesis, myelopoiesis and leukemia. His work on the Growth factor independent-1 (Gfi1) transcriptional repressor protein has spanned the initial identification of Gfi1 in a model of leukemia and the role of Gfi1 in normal myeloid biology, to the identification of GFI1 mutations in patients with severe congenital neutropenia (SCN) and non-immune chronic idiopathic neutropenia of adults (NI-CINA). His work bridges normal hematopoietic development and innate immune action with marrow failure and transformation. His lab does it all! Don’t miss this talk by a dynamic speaker!

NLM Title:	Coupling single-cell RNA-seq with tracking of regulatory determinants reveals rare hematopoietic transition states / H. Leighton Grimes ; Immunology Interest Group.
Author:	Grimes, H Leighton. National Institutes of Health (U.S.). Immunology Interest Group,
Publisher:
Abstract:	(CIT): Dr. Grimes received his Ph.D. in Molecular Pathology and Immunology studying gene regulation with Maureen Goodenow at the University of Florida, then joined Philip Tsichlis at Fox Chase Cancer Center, cloning novel genes activated by insertion mutagenesis (e.g. Akt, Tpl2). He has a broad background in hematopoiesis, molecular biology, and molecular oncology including modeling of hematopoiesis, myelopoiesis and leukemia. His work on the Growth factor independent-1 (Gfi1) transcriptional repressor protein has spanned the initial identification of Gfi1 in a model of leukemia and the role of Gfi1 in normal myeloid biology, to the identification of GFI1 mutations in patients with severe congenital neutropenia (SCN) and non-immune chronic idiopathic neutropenia of adults (NI-CINA). His work bridges normal hematopoietic development and innate immune action with marrow failure and transformation. His lab does it all! Don"t miss this talk by a dynamic speaker!.
Subjects:	Cell Differentiation Gene Expression Regulation Hematopoiesis--genetics
Publication Types:	Lecture Webcast

NLM Classification:	WH 140
NLM ID:	101674311
CIT Live ID:	18095
Permanent link:	https://videocast.nih.gov/watch=18095

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