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The Cell Biology of Genomes: From Fundamentals to Disease

Air date: Wednesday, April 10, 2013, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Description: Wednesday Afternoon Lecture Series, NIH Director's Lecture

In eukaryotes, genomes are housed and function in the cell nucleus. Although we have learned a great deal about the sequence of genomes and the machinery that reads genome information, we have only recently begun to gain insights into how genomes function in the context of the architectural framework of a living cell’s nucleus. Several key concepts such as the existence of nuclear architectural proteins, the presence of distinct nuclear compartments, the non-random organization of genomes, and the dynamic nature of nuclear architecture are now recognized as driving genome function. Importantly, aberrations in nuclear architecture are now known to lead to diseases ranging from cancer to premature aging. The elucidation of the cell biological properties of the genome will be essential to a full understanding of how genomes function in both health and disease. The principles of genome organization and examples of their roles in cancer and aging will be discussed in this lecture.
Author: Tom Misteli, Ph.D., National Cancer Institute, NIH
Runtime: 1 hour