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Selectivity of local circuits in the neocortex

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Air date: Monday, November 23, 2009, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 85 * This only includes stats from October 2011 and forward.
Category: Neuroscience
Runtime: 00:58:07
Description: Dr. Shaul Hestrin’s main research interest is to understand how the properties of neocortical neurons and the circuits they form give rise to cortical activity and function. The neocortex represents about 80% of the human brain and is associated with wide range of functions including sensory perception, motor movement, memory and higher aspects of cognition. Most of the synaptic connections that any cortical cell receives are from other cortical neurons, including GABAergic neurons. Thus, the interactions among cortical cells within the microcircuit play a critical role in determining cortical activity. His lab has developed methods to define cell types using genetics and other means, and then use brain slices to record simultaneously from individual neurons that are synaptically connected. These methods allow them to characterize the wiring pattern of microcircuits and the synaptic properties of specific connections. They also use calcium imaging to monitor the activity of large number of neurons. More recently he used optogenetic approaches to determine how external inputs affect the activity of cortical circuits.

NIH Neuroscience Seminar Series
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NLM Title: Selectivity of local circuits in the neocortex [electronic resource] / Shaul Hestrin.
Series: NIH neuroscience seminar series
Author: Hestrin, Shaul.
National Institutes of Health (U.S.)
Publisher:
Other Title(s): NIH neuroscience seminar series
Abstract: (CIT): Dr. Shaul Hestrin"s main research interest is to understand how the properties of neocortical neurons and the circuits they form give rise to cortical activity and function. The neocortex represents about 80% of the human brain and is associated with wide range of functions including sensory perception, motor movement, memory and higher aspects of cognition. Most of the synaptic connections that any cortical cell receives are from other cortical neurons, including GABAergic neurons. Thus, the interactions among cortical cells within the microcircuit play a critical role in determining cortical activity. His lab has developed methods to define cell types using genetics and other means, and then use brain slices to record simultaneously from individual neurons that are synaptically connected. These methods allow them to characterize the wiring pattern of microcircuits and the synaptic properties of specific connections. They also use calcium imaging to monitor the activity of large number of neurons. More recently he used optogenetic approaches to determine how external inputs affect the activity of cortical circuits. NIH Neuroscience Seminar Series.
Subjects: Neocortex--physiology
Publication Types: Lectures
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Download: To download this event, select one of the available bitrates:
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NLM Classification: WL 307
NLM ID: 101520530
CIT Live ID: 8291
Permanent link: https://videocast.nih.gov/launch.asp?15448

 

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