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Tracking Cytokine Expression in Allergic Immunity

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Air date: Wednesday, September 16, 2009, 4:15:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 129 * This only includes stats from October 2011 and forward.
Category: Immunology
Runtime: 01:06:17
Description: Dr. Locksley received his MD from the University of Rochester and did post-graduate training at UCSF as well as the University of Washington. He is a leading authority on the differentiation and function of CD4+ T lymphocytes in the context of both infection and allergy. Rich co-discovered the dichotomy in Th1/Th2 function that determines the outcome of Leishmania major infection and elucidated the critical regulatory role of Th2 derived IL-4 in disease exacerbation in this model. He and his colleagues at UCSF went on to describe the factors determining the development of Th1 vs Th2 responses in resistant vs susceptible mouse strains and helped identify the immunodominant LACK Ag, an important target for protective immunity in the L. major model. Rich and his group have also made fundamental discoveries concerning the regulation of the genes encoding IL-4 and the other Th2 cytokine family members and the basis of their co-ordinate regulation. This work led naturally to a major interest in cellular factors involved in the induction of Th2 inflammation and the recent discovery of the role of chitin and chitinases in the allergic response. Such studies have benefited enormously from the use of cytokine reporter mice, a tool co-pioneered by the Locksley group. Rich has enormous insights concerning the genetic basis and functional significance of CD4+ T cell subsets and in his role as director of the Sandler Center at UCSF has become a leading authority on immunologic approaches for intervention in Th2 inflammatory disease. Don't miss his exciting IIG seminar on "Tracking Cytokine Expression in Allergic Immunity"

The Immunology Interest Group
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NLM Title: Tracking cytokine expression in allergic immunity / Richard Locksley.
Author: Locksley, Richard M.
National Institutes of Health (U.S.)
Publisher:
Abstract: (CIT): Dr. Locksley received his MD from the University of Rochester and did post-graduate training at UCSF as well as the University of Washington. He is a leading authority on the differentiation and function of CD4+ T lymphocytes in the context of both infection and allergy. Rich co-discovered the dichotomy in Th1/Th2 function that determines the outcome of Leishmania major infection and elucidated the critical regulatory role of Th2 derived IL-4 in disease exacerbation in this model. He and his colleagues at UCSF went on to describe the factors determining the development of Th1 vs Th2 responses in resistant vs susceptible mouse strains and helped identify the immunodominant LACK Ag, an important target for protective immunity in the L. major model. Rich and his group have also made fundamental discoveries concerning the regulation of the genes encoding IL-4 and the other Th2 cytokine family members and the basis of their co-ordinate regulation. This work led naturally to a major interest in cellular factors involved in the induction of Th2 inflammation and the recent discovery of the role of chitin and chitinases in the allergic response. Such studies have benefited enormously from the use of cytokine reporter mice, a tool co-pioneered by the Locksley group. Rich has enormous insights concerning the genetic basis and functional significance of CD4+ T cell subsets and in his role as director of the Sandler Center at UCSF has become a leading authority on immunologic approaches for intervention in Th2 inflammatory disease. The Immunology Interest Group.
Subjects: Chitin--immunology
Cytokines--immunology
Immunity, Innate--immunology
Publication Types: Lectures
Webcasts
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NLM Classification: QW 568
NLM ID: 101516504
CIT Live ID: 8026
Permanent link: https://videocast.nih.gov/launch.asp?15300