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Dynamics of macromolecular complexes in living cells: Multiplex imaging of signaling activities, genetically encoded protein uncaging, and RapR-FAK

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Air date: Friday, May 23, 2008, 10:00:00 AM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 18 * This only includes stats from October 2011 and forward.
Category: Proteomics
Runtime: 00:48:05
Description: This talk will describe approaches to study and manipulate multiple nodes of a signaling pathway in living cells, revealing unexpected relationships between Rho family GTPases in motility. New methods for spatially and temporally controlled manipulation of protein activity will be described, including genetically encoded caged Rac, and Fak activated by drug treatment. These approaches may provide generally applicable tools to study signaling pathways in living cells.

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NLM Title: Dynamics of macromolecular complexes in living cells : multiplex imaging of signaling activities, genetically encoded protein uncaging, and rapR-FAK [electronic resource] / Klaus Hahn.
Series: Multiplex imaging of signaling activities, genetically encoded protein uncaging, and rapR-FAK
Author: Hahn, Klaus M.
National Institutes of Health (U.S.)
Publisher:
Other Title(s): Multiplex imaging of signaling activities, genetically encoded protein uncaging, and rapR-FAK
Abstract: (CIT): This talk will describe approaches to study and manipulate multiple nodes of a signaling pathway in living cells, revealing unexpected relationships between Rho family GTPases in motility. New methods for spatially and temporally controlled manipulation of protein activity will be described, including genetically encoded caged Rac, and Fak activated by drug treatment. These approaches may provide generally applicable tools to study signaling pathways in living cells.
Subjects: Cell Movement
Signal Transduction
rho GTP-Binding Proteins
Publication Types: Lectures
Webcasts
Rights: This is a work of the United States Government.
Download: To download this event, select one of the available bitrates:
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NLM Classification: QU 375
NLM ID: 101475736
CIT Live ID: 6787
Permanent link: https://videocast.nih.gov/launch.asp?14522