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Probing Unexpected Connections Between Cell Cycle Control and Pre-mRNA Splicing

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Air date: Friday, November 5, 2004, 9:45:00 AM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 15 * This only includes stats from October 2011 and forward.
Category: Proteomics
Runtime: 00:51:24
Description: The fission yeast cdc5 gene was identified in a genetic screen for mutants defective in cell cycle progression. Since that time, our laboratory and others have found that Cdc5p and its orthologs in other organisms including human are essential components of a subcomplex of the spliceosome termed the nineteen complex (NTC). Using Cdc5p as a target for tandem affinity purification, we have determined the composition (by mass spectrometry) and structure (by cryo-electron microscopy) of the assembled spliceosome.

For more information, visit
http://www.mc.vanderbilt.edu/vumcdept/cellbio/gould


http://proteome.nih.gov
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NLM Title: Probing unexpected connections between cell cycle control and pre-mRNA splicing [electronic resource] / Kathleen Gould.
Author: Gould, Kathleen.
National Institutes of Health (U.S.)
Publisher:
Abstract: (CIT): The fission yeast cdc5 gene was identified in a genetic screen for mutants defective in cell cycle progression. Since that time, our laboratory and others have found that Cdc5p and its orthologs in other organisms including human are essential components of a subcomplex of the spliceosome termed the nineteen complex (NTC). Using Cdc5p as a target for tandem affinity purification, we have determined the composition (by mass spectrometry) and structure (by cryo-electron microscopy) of the assembled spliceosome.
Subjects: Cell Cycle Proteins
Cell Cycle
Genes, cdc
RNA Splicing
Spliceosomes
Publication Types: Lectures
Webcasts
Rights: This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely.
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NLM Classification: QU 375
NLM ID: 101268606
CIT Live ID: 3682
Permanent link: https://videocast.nih.gov/launch.asp?12299