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This presentation will review how research in neuroscience might become clinically relevant. While the presentation will focus on one particular area, pediatric anxiety, the presentation will use this focus as a narrow example of a broader theme. In particular, the presentation will describe the range of questions that can be addressed in integrative research that translates neuroscience insights. All of these questions will draw heavily on brain-imaging work in humans, but some will draw equally heavily on work in other species whereas others will draw more heavily on the work in humans. This might illustrate one way in which neuroscience can become clinically relevant.