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Cancer and aging: rival demons?

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Air date: Wednesday, February 13, 2019, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 502, (243 Live, 259 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 00:56:22
Description: NIH Director’s Wednesday Afternoon Lecture Series

Cancer and aging are intricately intertwined. Organisms with dividing cells are at a substantial risk for developing cancer. Evolution “solved” the cancer problem by selecting for tumor suppressive mechanisms, which protect these organisms for cancer – at least for the reproductively active portion of the life span. Beyond that portion of the life span, these mechanisms can drive pathologies associated with aging, including, ironically, cancer. For her lecture, Dr. Campisi will discuss how one complex tumor suppressive mechanism termed cellular senescence is thought to drive a surprising number of age-associated diseases, and current strategies for maintaining tumor suppression while mitigating aging.
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NLM Title: Cancer and aging : rival demons? / Judith Campisi.
Author: Campisi, Judith.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): NIH Director's Wednesday Afternoon Lecture Series. Cancer and aging are intricately intertwined. Organisms with dividing cells are at a substantial risk for developing cancer. Evolution "solved" the cancer problem by selecting for tumor suppressive mechanisms, which protect these organisms for cancer - at least for the reproductively active portion of the life span. Beyond that portion of the life span, these mechanisms can drive pathologies associated with aging, including, ironically, cancer. For her lecture, Dr. Campisi will discuss how one complex tumor suppressive mechanism termed cellular senescence is thought to drive a surprising number of age-associated diseases, and current strategies for maintaining tumor suppression while mitigating aging.
Subjects: Aging
Cellular Senescence
Neoplasms--etiology
Publication Types: Lecture
Webcasts
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Caption Text: Download Caption File
NLM Classification: QZ 202
NLM ID: 101743234
CIT Live ID: 31425
Permanent link: https://videocast.nih.gov/launch.asp?27323