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Integrating Mass Spectrometry-based Proteomics and Lipidomics Reveals Biomarkers and Altered Signaling Pathways During Progressive Neurodegeneration in Niemann-Pick Disease, type C1

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Air date: Friday, February 8, 2019, 1:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 65, (17 Live, 48 On-demand)
Category: Proteomics
Runtime: 00:48:26
Description: Proteomics Interest Group

Advances in mass spectrometry technology have enabled large-scale differential analysis of proteins and lipids to investigate altered pathways in human disease. Our laboratory studies Niemann-Pick Disease, type C1 (NPC1) a lysosomal storage disorder with visceral involvement and progressive cerebellar neurodegeneration. Using a combination of differential proteomics, lipidomics and mass spectrometry imaging, we have identified new candidate biomarkers in a mouse model of NPC1. These alterations now provide a basis for evaluation in NPC1 patients and also can be used for therapeutic development. Several examples will be presented.

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Author: Dr. Stephanie Cologna, University of Illinois at Chicago
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CIT Live ID: 31416
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