CIT can broadcast your seminar, conference or meeting live to a world-wide
audience over the Internet as a real-time streaming video. The event can
be recorded and made available for viewers to watch at their convenience
as an on-demand video or a downloadable podcast. CIT can also broadcast
NIH-only or HHS-only content.
A central problem for 21st century science will be the analysis and understanding of the human genome. My talk will be concerned with topics within this area, in particular annotating pseudogenes (protein fossils) in the genome. I will discuss a comprehensive pseudogene identification pipeline and storage database we have built. This has enabled use to identify >10K pseudogenes in the human and mouse genomes and analyze their distribution with respect to age, protein family, chromosomal
location. One interesting finding is the large number of ribosomal pseudogenes in the human genome, with 80 functional ribosomal proteins giving rise to ~2,000 ribosomal protein pseudogenes. At end I will talk broadly about pseudogenes, in terms of their composition and mutation rates and I will compare pseudogenes in the human with those in a number of other model organisms, including worm, fly, yeast, and various prokaryotes.