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The BRAIN Initiative (Brain Research through Advancing Innovative Neurotechnologies) was launched in 2013 as a collaborative, public-private research partnership with the goal of facilitating the development and application of innovative technologies to understand brain function. Inspired by the Human Genome Project and born out of a Grand Challenge, the BRAIN Initiative seeks to revolutionize our understanding of the human brain. This session will provide an overview of neuroscience and neurotechnology research directions being pursued within the NIH Intramural Research Program as well as offer a panel discussion that will cover past activities and future directions of this innovative new program.