Skip Navigation


CIT can broadcast your seminar, conference or meeting live to a world-wide audience over the Internet as a real-time streaming video. The event can be recorded and made available for viewers to watch at their convenience as an on-demand video or a downloadable podcast. CIT can also broadcast NIH-only or HHS-only content.

Wiring the Developing Eye to the Brain for Binocular Vision

Loading video...

83 Views  
   
Air date: Monday, April 23, 2018, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 83, (31 Live, 52 On-demand)
Category: Neuroscience
Runtime: 01:10:16
Description: NIH Neuroscience Series Seminar

In Dr Mason lab’s studies of axon guidance in the visual pathways, they analyze the behaviors, cellular interactions and molecular directives of retinal axon growth cones during avoidance and crossing of the midline at the optic chiasm. This system is a model for axon navigation at the CNS midline, and for patterning the binocular projection. They have identified a molecular program of transcription factors and guidance receptors that regulate cell identity and projection of the ipsilateral retinal axon pathway through the optic chiasm. Current work aims to investigate transcriptional regulators and guidance mechanisms for the contralateral projection, and mechanisms of growth cone interactions with cells of the chiasm midline.

They have recently addressed whether the programs of gene expression that direct retinal axon decussation at the optic chiasm are relevant to the formation of connections of retinal axons in their first target, the lateral geniculate nucleus. They now aim to identify molecular regulators of axon-targeting and retinal ganglion cell axon arbor morphogenesis, and to analyze the interplay of molecular factors and neural activity in the targeting and refinement of eye-specific projections.

A genetic model for these studies is the albino. In both humans and rodents, lack of pigment in the eye leads to visual impairment due to the misrouting of retinal fibers at the optic chiasm to contralateral rather than ipsilateral targets. Albinism is caused by diverse genes controlling melanogenesis. They aim to study how factors in the melanogenic pathway from the retinal pigment epithelium (RPE) affect retinal patterning, and retinal ganglion cell specification and projection fate.

For more information go to https://neuroscience.nih.gov/neuroseries/Home.aspx
Debug: Show Debug
Author: Carol Mason, Ph.D., Columbia University, College of Physicians and Surgeons
Download: To download this event, select one of the available bitrates:
[64k]  [150k]  [240k]  [740k]  [1040k]  [1240k]  [1440k]  [1840k]    How to download a Videocast
Caption Text: Download Caption File
CIT Live ID: 24984
Permanent link: https://videocast.nih.gov/launch.asp?23838