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The last decade has seen unprecedented progress in Psychiatric Genomics and for the first-time real advances have been made in delineating the genetic architecture of neuropsychiatric disorders and their underlying molecular pathophysiology. This progress has been facilitated by a convergence in the understanding of the structure and function of the human genome; the development of high throughput sequencing technologies that can be deployed across molecular scales (e.g. DNA, RNA, methylation etc.) and the creation of large bio- and data- repositories. In parallel, the team science (TS) approach has been refined as a novel mechanism to create global large scale “collaboratories” that can efficiently and rapidly integrate samples, pipelines, data and brainpower to work on some of the hard problems in Neuropsychiatry. This symposium will provide a review of the state of the art in the field of Neuropsychiatric Genomics across the genomic landscape including gene discovery and regulation, causal/probabilistic modeling of disease states including functional follow up and behavioral and clinical outcomes. The use of rare genetic disorders as models of disease will be discussed. Results will be presented from Caucasian and non-Caucasian populations, including ancestral African population samples. The utility and the challenges of using large scale well curated brain banks and bio- and data- repositories will be highlighted. A focus of the symposium will be to explore the integrative and synergistic nature of these efforts, the inherent opportunities for advancing the field and to lay out a vision for the future of Neuropsychiatric Genomics.
Office of Genomics Research Coordination, National Institute of Mental Health, NIH