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A screen for small-molecule modulators of the unfolded protein response yielded ISRIB, a drug-like compound that with high efficacy renders cells insensitive to translational inhibition by phosphorylation of eIF2. ISRIB is an activator of eIF2B, eIF2's guanine nucleotide exchange factor, and a cognitive enhancer in rodents, significantly improving long-term memory of wild-type animals in behavioral assays.
Dr. Walter is the winner of the 2014 Lasker Award, 2014 Shaw Prize, and 2015 Vilcek Prize.
Peter Walter, Ph.D., Distinguished Professor of Biochemistry and Biophysics at University of California, San Francisco; Investigator, Howard Hughes Medical Institute