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New antibiotics from the microbial dark matter

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Air date: Wednesday, February 15, 2017, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 265, (143 Live, 122 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 00:58:16
Description: NIH Director's Wednesday Afternoon Lecture Series

We are experiencing an antibiotic crisis: Our ability to discover novel compounds has diminished and pathogens go largely unchecked in acquiring and spreading resistance. The main source of antibiotics–soil actinomycetes–has been overmined. In chronic infections, the problem is compounded by the presence of dormant persister cells that are resistant to all antibiotics. As a result, chronic osteomyelitis or infections in patients with cystic fibrosis can be untreatable. About 99 percent of environmental microorganisms are uncultured. Dr. Lewis’s lab developed approaches for killing persister cells and growing uncultured bacteria. The lab found that this "microbial dark matter" harbors novel antimicrobials that evolved to be essentially free of resistance.

For more information go to https://oir.nih.gov/wals/2016-2017
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Author: Kim Lewis, Ph.D., Director, Antimicrobial Discovery Center, Northeastern University
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CIT Live ID: 21817
Permanent link: https://videocast.nih.gov/launch.asp?21138