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Bone Marrow Aging and the PTH Receptor: A Model of Integrative Physiology

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Air date: Wednesday, February 1, 2017, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 249, (96 Live, 153 On-demand)
Category: Geroscience
Runtime: 01:02:51
Description: Trans-NIH GeroScience Interest Group (GSIG)

Dr. Cliff Rosen is a Senior Scientist and the Director of the Center for Clinical and Translational Research at the Maine Medical Center Research Institute (MMCRI). His laboratory studies the mesenchymal stem cell fate as it relates to the switch between pre-adipocytes and pre-osteoblasts. The focus of these efforts relates to cell autonomous factors such as substrate utilization and bioenergetics of the osteoblast and cell non-autonomous determinants such as parathyroid hormone and sympathetic tone. Dr. Rosen’s current projects, supported by the NIH, revolve around the origin and function of bone marrow fat cells; the role of IGFBP-2 in osteogenesis and the bioenergetics of the osteoblast; the impact of anabolic therapy for age-related osteoporosis on marrow adipose tissue; and whole body and cell phenotyping related to metabolic function in mice. Dr. Rosen is the past president of the American Society of Bone and Mineral Research. He served as an associate editor at Journal of Clinical Endocrinology and Metabolism, senior associate editor at the Journal of Bone and Mineral Research and Aging Cell. He is currently an Associate Editor at New England Journal of Medicine and eLife.

The GSIG was created to discuss and explore the complex relationships between the biology of aging and the biology of diseases and conditions that are of interest to various institutes and centers across the NIH. If you are interested in learning more, please visit the GSIG web site http://sigs.nih.gov/geroscience/Pages/default.axsp
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NLM Title: Bone marrow aging and the PTH receptor : a model of integrative physiology / Clifford J. Rosen ; Trans-NIH GeroScience Interest Group (GSIG).
Author: Rosen, Clifford J.
National Institutes of Health (U.S.). Geroscience Interest Group,
Publisher:
Abstract: (CIT): Trans-NIH GeroScience Interest Group (GSIG) Dr. Cliff Rosen is a Senior Scientist and the Director of the Center for Clinical and Translational Research at the Maine Medical Center Research Institute (MMCRI). His laboratory studies the mesenchymal stem cell fate as it relates to the switch between pre-adipocytes and pre-osteoblasts. The focus of these efforts relates to cell autonomous factors such as substrate utilization and bioenergetics of the osteoblast and cell non-autonomous determinants such as parathyroid hormone and sympathetic tone. Dr. Rosen"s current projects, supported by the NIH, revolve around the origin and function of bone marrow fat cells; the role of IGFBP-2 in osteogenesis and the bioenergetics of the osteoblast; the impact of anabolic therapy for age-related osteoporosis on marrow adipose tissue; and whole body and cell phenotyping related to metabolic function in mice. Dr. Rosen is the past president of the American Society of Bone and Mineral Research. He served as an associate editor at Journal of Clinical Endocrinology and Metabolism, senior associate editor at the Journal of Bone and Mineral Research and Aging Cell. He is currently an Associate Editor at New England Journal of Medicine and eLife. The GSIG was created to discuss and explore the complex relationships between the biology of aging and the biology of diseases and conditions that are of interest to various institutes and centers across the NIH.
Subjects: Aging--physiology
Bone Marrow--physiology
Osteoblasts--physiology
Osteogenesis--physiology
Receptors, Parathyroid Hormone--physiology
Publication Types: Lecture
Webcasts
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Caption Text: Download Caption File
NLM Classification: WH 380
NLM ID: 101702157
CIT Live ID: 21646
Permanent link: https://videocast.nih.gov/launch.asp?21119