CIT can broadcast your seminar, conference or meeting live to a world-wide
audience over the Internet as a real-time streaming video. The event can
be recorded and made available for viewers to watch at their convenience
as an on-demand video or a downloadable podcast. CIT can also broadcast
NIH-only or HHS-only content.
Dr. Choquet’s lab has a transdisciplinary approach to study the interplay between the organizational dynamics of the molecular components of glutamatergic synapses and synaptic transmission. Their projects build on their recent findings that:
trafficking of neuronal molecules such as glutamate receptors is highly dynamic,
regulations of protein-protein interactions play key roles in the control of this trafficking at different steps, including lateral diffusion, endo and exocytosis,
modulation of glutamate receptor trafficking has a profound impact on synaptic transmission, including on both short and long term post-synaptic plasticity.
By combining the expertise of chemists, biochemists, cell biologists, biophysicists and neurophysiologists, they will develop 3 main research axes:
dynamics and physical-chemistry of the macro-molecular complexes of the synapse,
nano-scale organization and dynamics of synaptic proteins and membrane trafficking,
impact of the dynamic of synapse organization on synaptic physiology.
Results obtained in these three axes will be constantly integrated to provide a global view of glutamatergic synapse physiology, from nano-scale interactions to function.