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Dissecting branching morphogenesis and coordinated wiring of the vascular and nervous systems

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Air date: Friday, January 29, 2016, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 178, (43 Live, 135 On-demand)
Category: NIH Director's Seminars
Runtime: 00:59:24
Description: Director's Seminar Series

Branching morphogenesis is a fundamental attribute of many organs. As examples of highly informative model systems, we have focused our studies on two major branching networks, the vascular and nervous systems, which share several anatomical and functional characteristics, and are often patterned similarly in peripheral tissues. Combining high-resolution whole-mount imaging, advanced genetic perturbations, and in vitro organ culture techniques, we are elucidating, at molecular level, how sensory nerves controls vascular branching morphogenesis and how sympathetic nerves are guided by neighboring blood vessels during organ development. Ongoing studies are focusing on understanding the developmental programs of branching morphogenesis and patterning in the neuro-vascular wiring at single cell resolution, how they restart these programs during tissue regeneration, and how they go awry in disease conditions including obesity-related nerve disorders.
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NLM Title: Dissecting branching morphogenesis and coordinated wiring of the vascular and nervous systems / Yosuke Mukoyama.
Author: Mukoyama, Yosuke.
Publisher:
Abstract: (CIT): Director's Seminar Series Branching morphogenesis is a fundamental attribute of many organs. As examples of highly informative model systems, we have focused our studies on two major branching networks, the vascular and nervous systems, which share several anatomical and functional characteristics, and are often patterned similarly in peripheral tissues. Combining high-resolution whole-mount imaging, advanced genetic perturbations, and in vitro organ culture techniques, we are elucidating, at molecular level, how sensory nerves controls vascular branching morphogenesis and how sympathetic nerves are guided by neighboring blood vessels during organ development. Ongoing studies are focusing on understanding the developmental programs of branching morphogenesis and patterning in the neuro-vascular wiring at single cell resolution, how they restart these programs during tissue regeneration, and how they go awry in disease conditions including obesity-related nerve disorders.
Subjects: Blood Vessels--growth & development
Morphogenesis
Neurogenesis
Publication Types: Lecture
Webcasts
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Caption Text: Download Caption File
NLM Classification: WG 500
NLM ID: 101678397
CIT Live ID: 18335
Permanent link: https://videocast.nih.gov/launch.asp?19457