NIH VideoCast - Neuronal Ensembles in Learned Behaviors in Addiction Research

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Neuronal Ensembles in Learned Behaviors in Addiction Research

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Air date:	Friday, December 18, 2015, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 255 (48 Live, 207 On-demand)
Category:	NIH Director's Seminars
Runtime:	01:02:14
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Director's Seminar Series Learned associations between drugs and environment play an important role in addiction and are thought to be encoded within specific patterns of sparsely distributed neurons called neuronal ensembles that are selected by drug- and environment-related cues. Similar neuronal ensembles are thought to mediate most learned behaviors. Until recently, nearly all studies of learning-specific neural mechanisms assessed neuroadaptations and mechanisms found in whole brain areas or cell types regardless of whether these neurons were activated or not during behavior. To address this problem, Dr. Hope pioneered the development of technologies and transgenic rat systems for identifying, examining, and manipulating Fos-expressing ensembles in addiction research, including the disruption of highly specific memories in conditioned drug behaviors. These studies open up the possibility of disrupting specific memories in addiction and other learning-based disorders in humans.

NLM Title:	Neuronal ensembles in learned behaviors in addiction research / Bruce Thomas Hope.
Author:	Hope, Bruce Thomas. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): Learned associations between drugs and environment play an important role in addiction and are thought to be encoded within specific patterns of sparsely distributed neurons called neuronal ensembles that are selected by drug- and environment-related cues. Similar neuronal ensembles are thought to mediate most learned behaviors. Until recently, nearly all studies of learning-specific neural mechanisms assessed neuroadaptations and mechanisms found in whole brain areas or cell types regardless of whether these neurons were activated or not during behavior. To address this problem, Dr. Hope pioneered the development of technologies and transgenic rat systems for identifying, examining, and manipulating Fos-expressing ensembles in addiction research, including the disruption of highly specific memories in conditioned drug behaviors. These studies open up the possibility of disrupting specific memories in addiction and other learning-based disorders in humans.
Subjects:	Behavior, Addictive--metabolism Illicit Drugs--pharmacology Nerve Net Neurons--physiology Substance-Related Disorders--metabolism
Publication Types:	Lecture Webcast

NLM Classification:	WM 176
NLM ID:	101676571
CIT Live ID:	18101
Permanent link:	https://videocast.nih.gov/watch=18101

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