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Neuronal Ensembles in Learned Behaviors in Addiction Research

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Air date: Friday, December 18, 2015, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 246, (48 Live, 198 On-demand)
Category: NIH Director's Seminars
Runtime: 01:02:14
Description: Director's Seminar Series

Learned associations between drugs and environment play an important role in addiction and are thought to be encoded within specific patterns of sparsely distributed neurons called neuronal ensembles that are selected by drug- and environment-related cues. Similar neuronal ensembles are thought to mediate most learned behaviors. Until recently, nearly all studies of learning-specific neural mechanisms assessed neuroadaptations and mechanisms found in whole brain areas or cell types regardless of whether these neurons were activated or not during behavior. To address this problem, Dr. Hope pioneered the development of technologies and transgenic rat systems for identifying, examining, and manipulating Fos-expressing ensembles in addiction research, including the disruption of highly specific memories in conditioned drug behaviors. These studies open up the possibility of disrupting specific memories in addiction and other learning-based disorders in humans.
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NLM Title: Neuronal ensembles in learned behaviors in addiction research / Bruce Thomas Hope.
Author: Hope, Bruce Thomas.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): Learned associations between drugs and environment play an important role in addiction and are thought to be encoded within specific patterns of sparsely distributed neurons called neuronal ensembles that are selected by drug- and environment-related cues. Similar neuronal ensembles are thought to mediate most learned behaviors. Until recently, nearly all studies of learning-specific neural mechanisms assessed neuroadaptations and mechanisms found in whole brain areas or cell types regardless of whether these neurons were activated or not during behavior. To address this problem, Dr. Hope pioneered the development of technologies and transgenic rat systems for identifying, examining, and manipulating Fos-expressing ensembles in addiction research, including the disruption of highly specific memories in conditioned drug behaviors. These studies open up the possibility of disrupting specific memories in addiction and other learning-based disorders in humans.
Subjects: Behavior, Addictive--metabolism
Nerve Net
Neurons--physiology
Street Drugs--pharmacology
Substance-Related Disorders--metabolism
Publication Types: Lecture
Webcasts
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Caption Text: Download Caption File
NLM Classification: WM 176
NLM ID: 101676571
CIT Live ID: 18101
Permanent link: https://videocast.nih.gov/launch.asp?19404