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The Staurosporin Nucleus, a Molecule(!) for All Diseases

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Air date: Tuesday, May 14, 2002, 2:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 5 * This only includes stats from October 2011 and forward.
Category: Special
Runtime: 00:39:29
Description: Mass Spectrometry Interest Group at the NCI-Frederick

Although staurosporin was originally identified as a PKC inhibitor, the more targets that this molecular scaffold has been exposed to, the more interesting it has become. Currently there are staurosporin "lookalikes" in clinical trials as drug candidates for topoisomerase I and II inhibition and Cyclin-dependent kinase inhibition. Not areas that one would assume, a priori, that the same basic molecule would be involved. Some thoughts that come to mind involve the possibilities for using such molecules as probes for targets and then the use of sensitive mass spectrometric techniques might well be able to show commonalities in binding sites, thus leading to improved designs for both screens and molecules. These areas will be discussed from both a natural product and also a synthetic perspective.

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NLM Title: The staurosporin nucleus, a molecule(!) for all diseases [electronic resource] / David Newman.
Author: Newman, David J.
National Institutes of Health (U.S.)
Subjects: Protein Kinase C--antagonists & inhibitors
Publication Types: Webcasts
Rights: This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely.
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NLM Classification: QU 143
NLM ID: 101267831
CIT Live ID: 1652
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