Skip Navigation


CIT can broadcast your seminar, conference or meeting live to a world-wide audience over the Internet as a real-time streaming video. The event can be recorded and made available for viewers to watch at their convenience as an on-demand video or a downloadable podcast. CIT can also broadcast NIH-only or HHS-only content.

Roles for Transcriptional Super-Enhancers in Cell Identity and Disease

Loading video...

724 Views  
   
Air date: Thursday, November 21, 2013, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 724, (143 Live, 581 On-demand)
Category: Special
Runtime: 01:03:38
Description: NHGRI DIR Genome Seminar

The Young laboratory studies super-enhancers (also known as stretch enhancers), which are large clusters of transcriptional enhancers that drive high-level expression of key cell identity genes. For many diseases, trait-associated sequence variation is especially enriched in the super-enhancers of disease-relevant cell types. Furthermore, the Young lab has found that cancer cells acquire super-enhancers at oncogenes and other genes important to tumor pathogenesis. In tumor cells, super-enhancer-driven oncogene expression can be exceptionally vulnerable to drugs that target transcriptional cofactors, suggesting new approaches to cancer therapy. Dr. Young’s lecture will describe recent results that further illuminate the roles of super-enhancers in control of cell identity and disease.
Debug: Show Debug
NLM Title: Roles for transcriptional super-enhancers in cell identity and disease / Dr. Richard Young.
Series: NHGRI DIR genome seminar
Author: Young, Richard A.
National Institutes of Health (U.S),
Publisher:
Other Title(s): NHGRI DIR genome seminar
Abstract: (CIT): NHGRI DIR Genome Seminar The Young laboratory studies super-enhancers (also known as stretch enhancers), which are large clusters of transcriptional enhancers that drive high-level expression of key cell identity genes. For many diseases, trait-associated sequence variation is especially enriched in the super-enhancers of disease-relevant cell types. Furthermore, the Young lab has found that cancer cells acquire super-enhancers as oncogenes and other genes important to tumor pathogenesis. In tumor cells, super-enhancer-driven oncogene expression can be exceptionally vulnerable to drugs that target transcriptional cofactors, suggesting new approaches to cancer therapy. Dr. Young's lecture will describe recent results that further illuminate the roles of super-enhancers in control of cell identity and disease.
Subjects: Enhancer Elements, Genetic
Neoplasms--genetics
Publication Types: Lectures
Webcasts
Download: To download this event, select one of the available bitrates:
[64k]  [150k]  [240k]  [440k]  [740k]  [1040k]    How to download a Videocast
Caption Text: Download Caption File
NLM Classification: QU 470
NLM ID: 101622767
CIT Live ID: 13371
Permanent link: https://videocast.nih.gov/launch.asp?18183