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Sirtuins, Aging and Disease

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Air date: Wednesday, November 19, 2008, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 92 * This only includes stats from October 2011 and forward.
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:07:00
Description: SIR2 and related genes are NAD-dependent deacetylases that slow aging in yeast, C. elegans, and Drosophila. In yeast and flies, SIR2 genes are also involved in the longevity conferred by dietary or calorie restriction (CR). The mammalian SIRT homologs are involved in changes in stress resistance and metabolism known to be associated with CR.

The CR diet not only extends life span in rodents, but also protects against many diseases of aging, including diabetes, cardiovascular disease, neurodegenerative disease, cancer and osteoporosis. In this talk, I will describe recent findings in the lab regarding SIRT1 function in specific mammalian tissues and in specific disease models. Our findings indicate a diverse array of effects exerted by SIRT1 in mammals.

The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
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NLM Title: Sirtuins, aging, and disease [electronic resource] / Leonard Guarente.
Series: NIH director's Wednesday afternoon lecture series
Author: Guarente, Leonard.
National Institutes of Health (U.S.)
Publisher:
Other Title(s): NIH director's Wednesday afternoon lecture series
Abstract: (CIT): SIR2 and related genes are NAD-dependent deacetylases that slow aging in yeast, C. elegans, and Drosophila. In yeast and flies, SIR2 genes are also involved in the longevity conferred by dietary or calorie restriction (CR). The mammalian SIRT homologs are involved in changes in stress resistance and metabolism known to be associated with CR. The CR diet not only extends life span in rodents, but also protects against many diseases of aging, including diabetes, cardiovascular disease, neurodegenerative disease, cancer and osteoporosis. In this talk, I will describe recent findings in the lab regarding SIRT1 function in specific mammalian tissues and in specific disease models. Our findings indicate a diverse array of effects exerted by SIRT1 in mammals.
Subjects: Aging--genetics
Disease Models, Animal
Sirtuins
Publication Types: Lectures
Webcasts
Download: To download this event, select one of the available bitrates:
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NLM Classification: QU 136
NLM ID: 101490650
CIT Live ID: 7021
Permanent link: https://videocast.nih.gov/launch.asp?14782

 

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