BEGIN:VCALENDAR VERSION:2.0 PRODID:VideoCast CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT SUMMARY:IIG Seminar - IL-15-induced bystander T cell activation in human viral disease. DTSTART:20230628T200000Z DTEND:20230628T211500Z DTSTAMP:20230710T205700Z UID:Videocast--49784 LOCATION:https://videocast.nih.gov/watch=49784 DESCRIPTION:Eui-Cheol Shin\nDr. Eui-Cheol Shin investigates mechanisms of immunopathogenesis\, immunosenescence\, T-cell exhaustion\, and human immune monitoring. Dr. Shin and his team have extensively demonstrated the pathological significance of bystander T cell activation in human disease by studying T cell responses in patients infected with viral diseases. His group has found that pre-existing bystander memory CD8+ T cells are unexpectedly activated by cytokines (e.g.\, IL-15) regardless of their antigen specificity\, causing liver cell damage through NKG2D-mediated cytotoxicity. In characterizing IL-15-responsive bystander T cells in the liver microenvironment\, Dr. Shin’s team has demonstrated that bystander T cells can be a significant cause of host injury in human viral infection. These studies have identified CD5 as a major negative regulator of IL-15-induced T cell proliferation and have further identified IFNg as a mediator of IL-15 production from epithelial cells. Following the COVID-19 outbreak\, Dr. Shin’s team demonstrated that SARS-CoV-2-specific CD8+ T cells - despite expressing PD-1 - remain functionally active. On the basis of these and subsequent findings\, Dr. Shin has recently proposed T cell-oriented strategies for controlling the COVID-19 pandemic. \n\nFor more information go to https://www.niaid.nih.gov/research/immunology-seminars https://www.niaid.nih.gov/research/immunology-seminars X-ALT-DESC;FMTTYPE=text/html:\n\n
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