BEGIN:VCALENDAR VERSION:2.0 PRODID:VideoCast CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT SUMMARY:NIH–FDA COVID SIG Lecture: Viral RNA Sensors in Human Immunity to SARS-CoV-2 DTSTART:20230629T160000Z DTEND:20230629T170000Z DTSTAMP:20230621T162100Z UID:Videocast--49181 LOCATION:https://videocast.nih.gov/watch=49181 DESCRIPTION:Helen Su\, M.D.\, Ph.D.\, NIAID\, NIH\nThis is an NIH–FDA COVID-19 SIG seminar talk. Helen Su\, M.D.\, Ph.D.\, is chief of the Human Immunological Diseases Section in NIAID. LECTURE SUMMARY: Impaired type I IFN responses can lead to life-threatening COVID-19. Previous reports have established that the endosomal viral RNA sensors TLR3 and TLR7 initiate protective type I IFN responses during SARS-CoV-2 infections in humans. However\, the role of the cytosolic RIG-I-like receptors (RLRs)\, which are more broadly expressed\, has been less well studied. We investigated rare variants in the genes encoding MDA5\, RIG-I\, and their downstream signaling adaptor MAVS\,from a large international cohort of SARS-CoV-2-infected subjects with varying disease severities. By identifying andfunctionally characterizing these variants\, as well as testing patients’ blood and fibroblasts\, we have delineated cross-regulatory positive amplification loops by which RLRs non-redundantly promote type I IFN responses in humans. Thus\, human variation in viral sensors can influence outcome to COVID-19 and possibly other respiratory viruses. LECTURE OBJECTIVES: (1) To understand the role of viral RNA sensors in initiatingand sustaining antiviral type I IFN responses\; (2) To appreciate how human genetic variation can modulate immune responses during viral infections. X-ALT-DESC;FMTTYPE=text/html:\n\n
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