BEGIN:VCALENDAR VERSION:2.0 PRODID:VideoCast CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT SUMMARY:IIG Seminar - Tissue-Resident Memory T cells in cancer. DTSTART:20230215T210000Z DTEND:20230215T221500Z DTSTAMP:20230224T234800Z UID:Videocast--48940 LOCATION:https://videocast.nih.gov/watch=48940 DESCRIPTION:Fathia Mami-Chouaïb\, Ph.D.\, Institut Gustave Roussy\nThe Mami-Chouaïb laboratory has identified several constitutive elements of the tumor environment (TME) involved in the regulation of antitumor T-cell response. In particular: the influence of TGF-β on the expression and signaling of CD103 in CD8+ resident memory T cells (TRM)\, and the role of this integrin to sustain specific cytotoxicity and to promote T-cell recruitment within epithelial tumor regions\; the role of hypoxia\, epithelial-mesenchymal transition (EMT) and p53 in controlling tumor cell susceptibility to T-cell-mediated killing\; and the effect of Von Hippel-Lindau (VHL) gene mutations in promoting PD-L1 expression on cancer cells and escape from anti-PD-1 therapies. The laboratory’s objective is to make new advances in the field of tumor resistance to T-cell-mediated cytotoxicity and immune checkpoint blockade (ICB) immunotherapy. Through its various aspects\, the aim of their research is to better understand how the TME influences the behavior and functions of effector T cells\, in particular TRM\, and impacts response to immunotherapies. Their goal is to improve current cancer treatments and contribute to the development of more effective combination therapies.\n\nFor more information go to 'https://www.niaid.nih.gov/research/immunology-seminars'>https://www.niaid.nih.gov/research/immunology-seminars X-ALT-DESC;FMTTYPE=text/html:\n\n
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