BEGIN:VCALENDAR VERSION:2.0 PRODID:VideoCast CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT SUMMARY:These Viruses Are Forever: Consequences of Retroviral DNA Integration to Aids and Evolution DTSTART:20210316T190000Z DTEND:20210316T200000Z DTSTAMP:20210419T181600Z UID:Videocast--41446 LOCATION:https://videocast.nih.gov/watch=41446 DESCRIPTION:John Coffin\, Ph.D.\, American Cancer Society Research Professor\, Tufts University School of Medicine\nWALS\n\nThis WALS lecture also is part of the Demystifying Medicine course series.\n\nJohn Coffin is an American Cancer Society Research Professor at Tufts University School of Medicine. He also maintains a joint position as a special advisor at the NCI Center for Cancer Research at NCI. His research interests revolve around obtaining a better understanding of the interaction of retroviruses with their host cells and organisms. He uses simple retroviruses (avian and murine viruses) as well as HIV to elucidate the nature of the retrovirus-receptor interaction.\n\nUnique among pathogens of eukaryotes\, retroviruses are distinctive in their replication through an obligate integrated DNA intermediate — the provirus — resulting in many biological consequences unique to this virus group. This talk will focus on two such consequences: the rich "fossil record" of infection of our primate ancestors for more than 100 million years in the form of endogenous proviruses\; and our inability\, despite the availability of highly effective viral treatments\, to cure HIV infection.\n\nFor more information go to https://oir.nih.gov/wals https://oir.nih.gov/wals X-ALT-DESC;FMTTYPE=text/html:\n\n
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