BEGIN:VCALENDAR VERSION:2.0 PRODID:VideoCast CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT SUMMARY:Demystifying Medicine - RNA Viruses: How They Do What They Do DTSTART:20210302T210000Z DTEND:20210302T230000Z DTSTAMP:20210303T215800Z UID:Videocast--41288 LOCATION:https://videocast.nih.gov/watch=41288 DESCRIPTION:Karla Kirkegaard\, PhD\, Stanford University and Nihal Altan Bonnet\, PhD\, NHLBI\, NIH\nDemystifying Medicine Lecture Series \n\nRNA viruses are among the most persistent and deadly known to humans and include the pathogens causing measles\, rabies\, polio\, Ebola\, dengue\, West Nile fever\, SARS\, MERS\, and our latest nemesis\, COVID-19. RNA viruses generally have very high mutation rates compared to DNA viruses\, which complicates the prevention and treatment of the diseases they cause. Their study\, however\, has led to broader insight into viral transmission in general. \n\nNihal Altan Bonnet\, Ph.D.\, is a senior investigator in the NHLBI Laboratory of Host-Pathogen Dynamics. Her multidisciplinary team of investigators combines tools of cell and molecular biology\, virology\, and immunology along with high-resolution imaging to understand how viruses transmit themselves effectively among hosts and establish successful infections. She has revealed novel roles for host membranes in mediating successful viral replication and transmission. \n\n Karla Kirkegaard\, Ph.D.\, is the Violetta L. Horton Research Professor of Genetics and recent former Chair of the Department of Microbiology and Immunology in the Stanford University School of Medicine. Her laboratory focuses on identification of dominant drug targets for antiviral design\, such as small molecules that stabilize oligomeric assemblages. A past recipient of the NIH Director's Pioneer Award\, Dr. Kirkegaard combines her interests in biochemistry\, cell biology\, and genetics in the study of RNA virology\, using poliovirus and other positive-strand RNA viruses to understand the cell biology of viral infections and the genetics of viral variability. X-ALT-DESC;FMTTYPE=text/html:\n\n
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