BEGIN:VCALENDAR VERSION:2.0 PRODID:VideoCast CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT SUMMARY:Immune Profiling to Understand COVID-19 Pathogenesis DTSTART:20201105T170000Z DTEND:20201105T180000Z DTSTAMP:20201105T142100Z UID:Videocast--38868 LOCATION:https://videocast.nih.gov/watch=38868 DESCRIPTION:John Wherry\, Ph.D.\, University of Pennsylvania\nNIH COVID-19 Scientific Interest Group \n\nDr. Wherry is the Richard and Barbara Schiffrin President's Distinguished Professor at the Perelman School of Medicine\, University of Pennsylvania\, Philadelphia. He studies T cell exhaustion in chronic infections and cancer and has helped define molecular mechanisms of T cell exhaustion through transcriptional and epigenetic studies\, including studies on the mechanisms by which immunoregulatory "checkpoint" pathways such as PD-1 control T cell exhaustion. \n\nDr. Wherry has helped uncover key features of inhibitory receptor blockade and co-blockade to reverse T cell exhaustion using transcriptional profiling\, genomics\, computational biology and multiparameter flow cytometry to understand the nature and reversibility of T cell exhaustion in preclinical and clinical settings. His laboratory has used these techniques to comprehensively study immune responses and immunophenotypes in response to SARS-CoV-2\, which will be the topic of his lecture. X-ALT-DESC;FMTTYPE=text/html:\n\n
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