BEGIN:VCALENDAR VERSION:2.0 PRODID:VideoCast CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT SUMMARY:Mining the Unexplored Cancer Kinome for Novel Therapeutic Targets in Squamous Cell Carcinomas DTSTART:20191213T170000Z DTEND:20191213T180000Z DTSTAMP:20191209T163000Z UID:Videocast--34820 LOCATION:https://videocast.nih.gov/watch=34820 DESCRIPTION:John Brognard\, Ph.D.\, Head\, Signaling Networks in Cancer Section\, Laboratory of Cell and Developmental Signaling Center for Cancer Research\, NCI\, NIH\nNCI’s Center for Cancer Research (CCR) Grand Rounds \n\nCancer genomic sequencing has significantly impacted the understanding of the temporal and spatial genetic alterations that lead to tumorigenesis. This information enables the development of targeted therapies that result in durable and less toxic responses in patients. In regard to kinases\, the biomedical community has focused research efforts on approximately 200 kinases among the 538 kinases present in the human kinome\, yet siRNA screens and cancer genomic studies indicate that the vast majority of these unexplored kinases (approximately 300) are implicated in cancer and harbour putative driver mutations. \n\nThe major focus of Dr. Brognard’s research is to elucidate novel cancer-associated kinases in the unexplored kinome\, guided by bioinformatics and functional genomic approaches\, with an overarching aim of understanding the molecular mechanisms utilized by these kinases to promote tumorigenesis. Through use of in vivo patient derived xenograft mouse models\, Dr. Brognard’s lab translates these findings to the clinic and encourages drug development programs focused on these novel targets. The overall goal is to provide a platform for transformational research to identify novel druggable drivers so that the vast majority of cancer patients can begin to benefit from precision medicine-based targeted therapies. Collectively\, Dr. Brognard’s research seeks to identify new genetic drivers\, targets for therapeutic intervention and novel mechanisms of tumorigenesis. For more information about Dr. Brognard\, please visit https://ccr.cancer.gov/Laboratory-of-Cell-and-Developmental-Signaling/john-brognard. X-ALT-DESC;FMTTYPE=text/html:\n\n
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