BEGIN:VCALENDAR VERSION:2.0 PRODID:VideoCast CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT SUMMARY:Expanding the functional and actionable genome: Insights from the study of fusion-driven tumors DTSTART:20190308T170000Z DTEND:20190308T180000Z DTSTAMP:20190304T184600Z UID:Videocast--28988 LOCATION:https://videocast.nih.gov/watch=28988 DESCRIPTION:Natasha J. Caplen\, Ph.D.\, Investigator\, Genetics Branch\, Head\, Functional Genetics Section\,Center for Cancer Research\, NCI\, NIH\nCCR Grand Rounds \n\nDr. Caplen co-discovered RNA interference (RNAi) in mammalian cells and has pioneered approaches for exploiting this gene regulatory mechanism to investigate cancer biology and treatment. Dr. Caplen applies the perturbations induced by RNA- or DNA-based technologies to interrogate specific aspects of the genetic\, transcriptional\, and cell-signaling alterations observed in cancer cells. These functional genetic approaches will be used to enhance our understanding of the mechanistic basis of cancer and to discover new cancer treatment strategies. Current studies are focused on the functional genetic analysis of cancers driven by fusion oncogenes. For more information about the speaker please visit 'https://ccr.cancer.gov/Genetics-Branch/natasha-j-caplen'>https://ccr.cancer.gov/Genetics-Branch/natasha-j-caplen X-ALT-DESC;FMTTYPE=text/html:\n\n
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