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Seymour J. Kreshover Lecture - Targeting Glia to Treat Chronic Pain: Moving from Concept to Clinical Trials

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Air date: Monday, May 4, 2015, 2:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 416, (87 Live, 329 On-demand)
Category: Special
Runtime: 01:13:14
Description: NIDCR 2015 Seymour J. Kreshover Lecture

Dr. Linda Watkins is a University of Colorado President's Teaching Scholar and the Director of the Interdepartmental Neuroscience PhD Program. She has held several NIH research grants, including grants from NIDCR, NIDA, NIMH, and NINDS.

Dr. Watkins’ research is focused on how to control chronic pain and increase the effectiveness of analgesics while minimizing their side effects. When non-neuronal cells known as glia are activated, they can create persistent, amplified neuroinflammation, thereby promoting the transition from acute to chronic pain. Dr. Watkins’ work has shown that glial activation can also compromise the ability of opioids to suppress chronic pain, contributing to the development of drug tolerance and dependence. Her findings have advanced our understanding of how therapeutics that target a specific glial activation receptor are effective stand-alone treatments for chronic pain and can also increase the efficacy of opioids while decreasing analgesic tolerance and dependence. Two such drugs, developed in the Watkins lab, are moving toward clinical trials.

NIDCR established the NIDCR Seymour J. Kreshover Lecture as a tribute to the late Seymour Kreshover, DDS, MD, PhD, who served as director of the (then) National Institute of Dental Research from 1966–1975. Lectures are delivered by outstanding investigators who have made significant contributions to research that impacts the dental, oral, and craniofacial field.

For more information go to http://www.nidcr.nih.gov/NewsAndFeatures/Announcements/Kreshover-2015.htm
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NLM Title: Targeting glia to treat chronic pain : moving from concept to clinical trials / Linda R. Watkins.
Author: Watkins, Linda R.
National Institute of Dental and Craniofacial Research (U.S.),
Publisher:
Abstract: (CIT): When non-neuronal cells known as glia are activated, they can create persistent, amplified neuroinflammation, thereby promoting the transition from acute to chronic pain. Dr. Watkins' work has shown that glial activation can also compromise the ability of opioids to suppress chronic pain, contributing to the development of drug tolerance and dependence. Her findings have advanced our understanding of how therapeutics that target a specific glial activation receptor are effective stand-alone treatments for chronic pain and can also increase the efficacy of opioids while decreasing analgesic tolerance and dependence. Two such drugs, developed in the Watkins lab, are moving toward clinical trials.
Subjects: Analgesics, Opioid--therapeutic use
Chronic Pain--drug therapy
Chronic Pain--metabolism
Drug Delivery Systems
Neuroglia--metabolism
Publication Types: Lecture
Webcasts
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Caption Text: Download Caption File
NLM Classification: WL 704.6
NLM ID: 101660621
CIT Live ID: 16118
Permanent link: https://videocast.nih.gov/launch.asp?18981