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Demystifying Medicine 2019 - Autoimmunity: Basic and Clinical Advances and Challenges

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Air date: Tuesday, April 23, 2019, 4:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 329, (90 Live, 239 On-demand)
Category: Demystifying Medicine
Runtime: 01:31:33
Description: Demystifying Medicine

Autoimmunity refers to a system of immune responses gone awry, tantamount to an attack against the body's own healthy cells and tissues with painful and often fatal consequences. This enemy within manifests itself in myriad ways, from targeted attacks (e.g., rheumatoid arthritis leading to debilitating joint damage) to multi-organ incursions (e.g. lupus and its effect on lungs, kidneys, nerves, and blood cells).

Upwards of 10 percent of Americans live with an autoimmune disease, making this the third most common disease category after cancer and heart disease. But who or what issues these ill-conceived orders to the immune system? And can the orders be intercepted or revoked?

For this next and antepenultimate lecture in the Demystifying Medicine 2019 series, we bring you two speakers who are on the frontlines of the battle against autoimmune diseases. Ron Germain, an NIH Distinguished Investigator in the NIAID Lymphocyte Biology Section, has made numerous contributions to the understanding of the cell biology of antigen processing. His group has pioneered methods of intravital 2-photon imaging to provide real-time, high-resolution visualization of immune-cell dynamics in situ, in the battlefield.

Co-presenter James Katz is the NIAMS Rheumatology Fellowship program director and the principal investigator for general arthritis protocols. Through the NIAMS Community Health Clinic, Katz has broadened the clinical exposure of NIAMS Rheumatology Fellows and has recruited patients from underrepresented groups with rheumatic diseases to better probe the etiology of rheumatoid arthritis, an ancient plague.

The Demystifying Medicine Lecture Series is designed to help bridge the gap between advances in biology and their applications to major human diseases. The lectures include presentations of patients, pathology, diagnosis, and therapy in the context of major diseases and current research. All clinicians, trainees including fellows, medical students, Ph.D. students, and other healthcare and research professionals are welcome to attend. For more information, please visit the Demystifying Medicine website at https://demystifyingmedicine.od.nih.gov.

For more information go to https://demystifyingmedicine.od.nih.gov
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NLM Title: Demystifying medicine 2019. Autoimmunity : basic and clinical advances and challenges / James Katz and Ronald Germain.
Author: Katz, James D.
Germain, Ron.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): Demystifying Medicine. Autoimmunity refers to a system of immune responses gone awry, tantamount to an attack against the body's own healthy cells and tissues with painful and often fatal consequences. This enemy within manifests itself in myriad ways, from targeted attacks (e.g., rheumatoid arthritis leading to debilitating joint damage) to multi-organ incursions (e.g. lupus and its effect on lungs, kidneys, nerves, and blood cells). Upwards of 10 percent of Americans live with an autoimmune disease, making this the third most common disease category after cancer and heart disease. But who or what issues these ill-conceived orders to the immune system? And can the orders be intercepted or revoked? For this next and antepenultimate lecture in the Demystifying Medicine 2019 series, we bring you two speakers who are on the frontlines of the battle against autoimmune diseases. Ron Germain, an NIH Distinguished Investigator in the NIAID Lymphocyte Biology Section, has made numerous contributions to the understanding of the cell biology of antigen processing. His group has pioneered methods of intravital 2-photon imaging to provide real-time, high-resolution visualization of immune-cell dynamics in situ, in the battlefield. Co-presenter James Katz is the NIAMS Rheumatology Fellowship program director and the principal investigator for general arthritis protocols. Through the NIAMS Community Health Clinic, Katz has broadened the clinical exposure of NIAMS Rheumatology Fellows and has recruited patients from underrepresented groups with rheumatic diseases to better probe the etiology of rheumatoid arthritis, an ancient plague. The Demystifying Medicine Lecture Series is designed to help bridge the gap between advances in biology and their applications to major human diseases. The lectures include presentations of patients, pathology, diagnosis, and therapy in the context of major diseases and current research. All clinicians, trainees including fellows, medical students, Ph.D. students, and other healthcare and research professionals are welcome to attend.
Subjects: Arthritis, Rheumatoid
Autoimmune Diseases--diagnostic imaging
Autoimmunity
Optical Imaging
Publication Types: Lecture
Webcasts
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NLM Classification: WE 346
NLM ID: 101746772
CIT Live ID: 31939
Permanent link: https://videocast.nih.gov/launch.asp?27457