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How to bust up a bacterial biofilm

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Air date: Wednesday, March 27, 2019, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 387, (129 Live, 258 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 00:50:39
Description: NIH Director's Wednesday Afternoon Lecture Series

The Bakaletz laboratory’s research focus is attempting to understand the pathogenic mechanisms operational in the highly prevalent pediatric disease, otitis media (OM) (or middle ear infection). Specifically, we are interested in elucidating how upper respiratory tract viruses predispose the middle ear to invasion by any of the three predominant bacterial pathogens of OM (nontypeable Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae). We are also interested in understanding how bacterial biofilms contribute to the recurrence and chronicity of OM, chronic rhinosinusitis, bronchitis, chronic cough and exacerbations of both COPD and CF. With this enhanced understanding, we then attempt to identify potential molecular targets for the design, development and pre-clinical testing of novel vaccine candidates or therapeutics using an animal model of viral-bacterial superinfection that closely mimics the polymicrobial nature of OM in children. Our long-term goal is to develop novel methods to more effectively treat or preferably, to prevent, otitis media and other respiratory tract infections where there is a biofilm component to the disease course.

For more information go to https://oir.nih.gov/wals/2018-2019/how-bust-bacterial-biofilm
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NLM Title: How to bust up a bacterial biofilm / Lauren O. Bakaletz.
Author: Bakaletz, Lauren O.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): The Bakaletz laboratory's research focus is attempting to understand the pathogenic mechanisms operational in the highly prevalent pediatric disease, otitis media (OM) (or middle ear infection). Specifically, we are interested in elucidating how upper respiratory tract viruses predispose the middle ear to invasion by any of the three predominant bacterial pathogens of OM (nontypeable Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae). We are also interested in understanding how bacterial biofilms contribute to the recurrence and chronicity of OM, chronic rhinosinusitis, bronchitis, chronic cough and exacerbations of both COPD and CF. With this enhanced understanding, we then attempt to identify potential molecular targets for the design, development and pre-clinical testing of novel vaccine candidates or therapeutics using an animal model of viral-bacterial superinfection that closely mimics the polymicrobial nature of OM in children. Our long-term goal is to develop novel methods to more effectively treat or preferably, to prevent, otitis media and other respiratory tract infections where there is a biofilm component to the disease course.
Subjects: Anti-Bacterial Agents--pharmacology
Bacterial Physiological Phenomena
Biofilms
Otitis Media--drug therapy
Otitis Media--microbiology
Publication Types: Lecture
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Caption Text: Download Caption File
NLM Classification: WV 232
NLM ID: 101744889
CIT Live ID: 31771
Permanent link: https://videocast.nih.gov/launch.asp?27402