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Mass spectrometry provides multiple options for the direct characterization of tissue to support surgical decision-making, and provides significant insight in the development of drugs targeting tumors of the central nervous system (CNS). Using an array of mass spectrometry (MS) applications, we rapidly analyze specific tumor markers ranging from small metabolites to proteins from surgical tissue for rapid diagnosis and surgical guidance. Using similar clinical protocols, we visualize drug and metabolites penetration in brain tumor tissue and correlate with tumor heterogeneity and response to support drug development.
Nathalie Agar, Ph. D., Director of the Surgical Molecular Imaging Laboratory (SMIL),Department of Neurosurgery, Brigham and Women’s Hospital, Associate Professor of Neurosurgery and Radiology, Harvard Medical School