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From Germline Genetics to Function: Making Sense of Genome-Wide Association Studies for Pancreatic Cancer Risk

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Air date: Friday, March 9, 2018, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 176, (104 Live, 72 On-demand)
Category: NIH Director's Seminars
Runtime: 00:57:14
Description: NIH Directors Seminar Series

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths in the United States and the seventh world-wide. This seminar will discuss results from genome-wide association studies (GWAS), conducted within the NCI-led Pancreatic Cancer Cohort Consortium. This collaborative effort has identified over 20 common pancreatic cancer risk loci. Genomic and functional characterization of a subset of these loci will be presented. These examples highlight different molecular mechanisms underlying cancer risk and genes found to be important for a wide range of processes including telomere maintenance, RNA surveillance and pancreatic development and homeostasis.
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NLM Title: From germline genetics to function : making sense of genome-wide association studies for pancreatic cancer risk / Laufey Amundadottir.
Author: Amundadottir, Laufey.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): NIH Directors Seminar Series Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths in the United States and the seventh world-wide. This seminar will discuss results from genome-wide association studies (GWAS), conducted within the NCI-led Pancreatic Cancer Cohort Consortium. This collaborative effort has identified over 20 common pancreatic cancer risk loci. Genomic and functional characterization of a subset of these loci will be presented. These examples highlight different molecular mechanisms underlying cancer risk and genes found to be important for a wide range of processes including telomere maintenance, RNA surveillance and pancreatic development and homeostasis.
Subjects: Carcinoma, Pancreatic Ductal--genetics
Genome-Wide Association Study--methods
Risk Factors
Publication Types: Lecture
Webcasts
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Caption Text: Download Caption File
NLM Classification: WI 810
NLM ID: 101724466
CIT Live ID: 27321
Permanent link: https://videocast.nih.gov/launch.asp?23748