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Dr. State Lab studies the genetics and genomics of developmental neuropsychiatric disorders, with a particular interest in Autism Spectrum Disorder (ASD), Tourette Disorder (TD), and Childhood-Onset Schizophrenia (COS). Historically, their research has focused on the contribution of rare variation to these conditions, as the identification of rare mutations with relatively large effects can provide insights into underlying pathophysiological mechanisms. As the field has found increasing success in gene discovery, their lab has increasingly focused on leveraging complex genetic architectures to identify tractable treatment targets and strategies. They use a wide range of genomic technologies including high-throughput sequencing (genome, exome, RNA-Seq), genotyping microarrays, and traditional molecular biology and model systems approaches.