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The Trans-NIH GeroScience Interest Group (GSIG), cordially invites you to its summer seminar, featuring Dr. Emmanuelle Passegué. Dr. Passegue is a Professor in the Department of Genetics and Development at the Columbia University Medical Center and Director of the Columbia Stem Cell Initiative (CSCI) in New York. She is widely recognized for her expertise on hematopoietic stem cell (HSC) biology. Her research over the past 10-years has focused on understanding the cellular and molecular processes controlling HSC activity during homeostasis, and addressing how these regulations are changed in myeloid malignancies and physiological aging. Her laboratory employs a variety of cross-disciplinary approaches using mouse models and human patient samples to identify genetic and/or molecular pathways as therapeutic targets to treat human diseases. Current projects investigate the role of apoptosis, autophagy, immune regulations, DNA repair mechanisms, and changes in the bone marrow niche microenvironment in HSC function in normal, stress, leukemic and aging conditions.
The GSIG was created to discuss and explore the complex relationships between the biology of aging and the biology of diseases and conditions that are of interest to various institutes and centers across the NIH.