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Structural biology of gene, epigenetic and immune regulation

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Air date: Wednesday, June 21, 2017, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 249, (113 Live, 136 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:11:08
Description: NIH Director’s Wednesday Afternoon Lecture Series

The role of RNA in information transfer and catalysis highlights its dual functionalities. Much of Dr. Patel's laboratory effort in this area has focused on metabolite-sensing riboswitches and nucleolytic self-cleaving ribozymes on the one hand, and on CRISPR-Cas systems on the other. His WALS lecture will provide a few examples of the principles underlying metabolite recognition by riboswitches; his lab's studies on catalytic mechanisms adopted by nucleolytic ribozymes; recent x-ray and cryoEM studies on ternary complexes of Cas nucleases and multisubunit cascades with bound crRNA and target DNA; and the impact of anti-CRISPR proteins in suppressing the CRISPR-Cas host-defense pathway.

For more information go to https://oir.nih.gov/wals
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NLM Title: Structural biology of gene, epigenetic, and immune regulation / Dinshaw J. Patel.
Author: Patel, Dinshaw.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): The role of RNA in information transfer and catalysis highlights its dual functionalities. Much of Dr. Patel's laboratory effort in this area has focused on metabolite-sensing riboswitches and nucleolytic self-cleaving ribozymes on the one hand, and on CRISPR-Cas systems on the other. His WALS lecture will provide a few examples of the principles underlying metabolite recognition by riboswitches; his lab's studies on catalytic mechanisms adopted by nucleolytic ribozymes; recent x-ray and cryoEM studies on ternary complexes of Cas nucleases and multisubunit cascades with bound crRNA and target DNA; and the impact of anti-CRISPR proteins in suppressing the CRISPR-Cas host-defense pathway.
Subjects: CRISPR-Cas Systems--genetics
Clustered Regularly Interspaced Short Palindromic Repeats
RNA, Catalytic--genetics
Riboswitch--physiology
Publication Types: Lectures
Webcasts
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Caption Text: Download Caption File
NLM Classification: QU 58.7
NLM ID: 101710184
CIT Live ID: 23702
Permanent link: https://videocast.nih.gov/launch.asp?23370