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Imaging lesion development and repair in multiple sclerosis

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Air date: Friday, June 16, 2017, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 114, (57 Live, 57 On-demand)
Category: NIH Director's Seminars
Runtime: 01:11:50
Description: NIH Director's Seminar Series

Does the white matter lesion in multiple sclerosis (MS) still matter in the age of highly effective disease-modifying therapy, which acts primarily to stop new lesions from forming? Evidence suggests that it does – not just because the most effective therapies are also the riskiest, but also because therapies that stop new lesions from forming do not appear to impact chronic inflammation or enhance repair. In this seminar, Dr. Reich will discuss his lab’s findings from the past few years about the development and early repair of white matter lesions in MS, and how those findings are mirrored in inflammatory demyelinating lesions in a primate model of MS. Dr. Reich will describe pathological changes that occur prior to demyelination and show how failed early repair can lead to smoldering inflammation at the lesion edge, with its attendant slow myelin destruction. He will also report on progress in imaging the recently described meningeal lymphatic system.
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NLM Title: Imaging lesion development and repair in multiple sclerosis / Daniel S. Reich.
Author: Reich, Daniel S.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): Does the white matter lesion in multiple sclerosis (MS) still matter in the age of highly effective disease-modifying therapy, which acts primarily to stop new lesions from forming? Evidence suggests that it does - not just because the most effective therapies are also the riskiest, but also because therapies that stop new lesions from forming do not appear to impact chronic inflammation or enhance repair. In this seminar, Dr. Reich will discuss his lab's findings from the past few years about the development and early repair of white matter lesions in MS, and how those findings are mirrored in inflammatory demyelinating lesions in a primate model of MS. Dr. Reich will describe pathological changes that occur prior to demyelination and show how failed early repair can lead to smoldering inflammation at the lesion edge, with its attendant slow myelin destruction. He will also report on progress in imaging the recently described meningeal lymphatic system.
Subjects: Multiple Sclerosis--diagnostic imaging
White Matter--diagnostic imaging
White Matter--physiopathology
Publication Types: Lectures
Webcasts
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Caption Text: Download Caption File
NLM Classification: WL 360
NLM ID: 101708398
CIT Live ID: 23706
Permanent link: https://videocast.nih.gov/launch.asp?23361