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John Daly Lecture: From the Jungle to the Synchrotron - Seven Millennia of Discovering Medicines Targeting G Protein-coupled Receptors

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Air date: Wednesday, May 17, 2017, 2:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 149, (65 Live, 84 On-demand)
Category: Special
Runtime: 00:59:25
Description: John Daly Lecture 2017

G protein-coupled receptors (GPCRs) are the largest family of related proteins in the human body and the site of action of around 300f prescription drugs. Drugs that target GPCRs derived from plants such as opioids, cannabinoids and alkaloids have been used as medicines for thousands of years without an understanding of their mechanism of action. Today advances in X-ray crystallography and biophysics are changing the face of GPCR drug discovery, enabling a precise understanding of the mechanisms of action of these drugs. GPCR x-ray structures are revealing an unexpected diversity in allosteric binding sites found on receptors and open up new opportunities for drug design. This lecture will provide an introduction to GPCRs, including some of the history of GPCR drug discovery finishing with an up-to-date description of the latest developments in our understanding of GPCR structures and their use in structure-based drug discovery.

Dr. Marshall will deliver her lecture in memory of Dr. John Daly, a noted natural products chemist and pharmacologist in NIDDK.
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NLM Title: From the jungle to the synchrotron : seven millennia of discovering medicines targeting G protein-coupled receptors / Dr. Fiona Marshall.
Author: Marshall, Fiona.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): John Daly Lecture 2017 G protein-coupled receptors (GPCRs) are the largest family of related proteins in the human body and the site of action of around 300f prescription drugs. Drugs that target GPCRs derived from plants such as opioids, cannabinoids and alkaloids have been used as medicines for thousands of years without an understanding of their mechanism of action. Today advances in X-ray crystallography and biophysics are changing the face of GPCR drug discovery, enabling a precise understanding of the mechanisms of action of these drugs. GPCR x-ray structures are revealing an unexpected diversity in allosteric binding sites found on receptors and open up new opportunities for drug design. This lecture will provide an introduction to GPCRs, including some of the history of GPCR drug discovery finishing with an up-to-date description of the latest developments in our understanding of GPCR structures and their use in structure-based drug discovery. Dr. Marshall will deliver her lecture in memory of Dr. John Daly, a noted natural products chemist and pharmacologist in NIDDK.
Subjects: Drug Discovery--history
Receptors, G-Protein-Coupled--drug effects
Receptors, G-Protein-Coupled--history
Publication Types: Lectures
Webcasts
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NLM Classification: QU 55.7
NLM ID: 101706998
CIT Live ID: 23387
Permanent link: https://videocast.nih.gov/launch.asp?23292