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Innate allergy

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Air date: Wednesday, April 5, 2017, 4:15:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 205, (59 Live, 146 On-demand)
Category: Immunology
Runtime: 00:58:03
Description: Immunology Interest Group Seminar Series

Despite clear roles for classical arms of immunity in maintenance of a healthy commensal microbial flora and protection from invasive pathogenic organisms, the purpose of allergic immunity, which underlies increasingly prevalent diseases like food allergy, asthma and atopic dermatitis, remains puzzling. The discovery of innate lymphoid cells that are programmed to produce cytokines associated with allergic immunity has provided new opportunities to assess basal physiologic processes that involve this canonical tissue response, and may reveal opportunities for re-tuning this arm of immunity to enhance health and well-being.

Richard Locksley is the Sandler Distinguished Professor, a Howard Hughes Medical Institute Investigator, and Director of the Sandler Asthma Basic Research Center at the University of California San Francisco (UCSF). He obtained his A.B. from Harvard, M.D. from the University of Rochester, Internal Medicine Residency at UCSF, and Infectious Diseases Fellowship at the University of Washington. His lab studies innate and adaptive immunity using infectious and inflammatory disease models, focusing on cytokines as critical mediators of biology. His salient contributions have elucidated the roles of cytokines as regulators of adaptive and innate immunity, and he pioneered the development of mice containing incorporated reporter systems that have enabled interrogation of the immune system in vivo. He has focused on Th2-related immunity to helminths and allergens, discovered Group 2 innate lymphoid cells (ILC2s), and delineated of the function of tuft cells as producers of IL-25 in intestinal type 2 immune responses. A major direction and focus of his seminar relates to the pathways by which type 2 immune responses are integrated into homeostasis of organs and tissues and the processes used to activate these responses in asthma, allergy, and in immunity to parasitic helminths. Dr. Locksley has served on major editorial boards and has received numerous awards and honors. He is a member of the American Society for Clinical Investigation (ASCI), Association of American Physicians (AAP), and was the first recipient of the William Paul Award for Cytokine Research by the International Cytokine & Interferon Society. Moreover, he is member of the American Academy of Arts and Sciences, a Member of the Albert Lasker Basic Medical Research Awards Jury and serves on the National Advisory Committee, Pew Scholars Program in Biomedical Sciences.
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NLM Title: Innate allergy / Dr. Richard Locksley.
Author: Locksley, Richard M.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): Despite clear roles for classical arms of immunity in maintenance of a healthy commensal microbial flora and protection from invasive pathogenic organisms, the purpose of allergic immunity, which underlies increasingly prevalent diseases like food allergy, asthma and atopic dermatitis, remains puzzling. The discovery of innate lymphoid cells that are programmed to produce cytokines associated with allergic immunity has provided new opportunities to assess basal physiologic processes that involve this canonical tissue response, and may reveal opportunities for re-tuning this arm of immunity to enhance health and well-being.
Subjects: Hypersensitivity--immunology
Immunity, Innate--immunology
Publication Types: Lectures
Webcasts
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Caption Text: Download Caption File
NLM Classification: QW 900
NLM ID: 101705346
CIT Live ID: 18586
Permanent link: https://videocast.nih.gov/launch.asp?23215