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Roles of regulatory RNAs & RNA-binding proteins in (re)programming patterns of gene expression

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Air date: Friday, November 18, 2016, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 149, (51 Live, 98 On-demand)
Category: NIH Director's Seminars
Runtime: 01:01:59
Description: NIH Director's Seminar Series

The Integrative Immunobiology Section is interested in understanding how gene expression programs are orchestrated in our cells, particularly stem cells. Specifically, the laboratory studies how these systems are controlled by non-coding RNAs and RNA-binding proteins. Our major goal is to discover novel molecular circuits that control cell fates in the hematopoietic and immune systems, since perturbations in their genetic regulatory networks underlie many diseases. To address these fundamental issues, we employ an integrative systems biology approach to reverse engineer the molecular logic of cell fate determination. We combine genome- and transcriptome-wide measurements with experimental perturbations in order to test and refine our models. As one example of our success, we identified the RNA-binding protein Lin28b as a lineage-determining factor for fetal hematopoietic stem cells, a discovery with potentially important implications for Regenerative and Precision Medicine. At a basic level, we demonstrate the concept of post-transcriptional (re)programming of cell fate decisions.
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NLM Title: Roles of regulatory rNAs & rNA-binding proteins in (re)programming patterns of gene expression / Stefan Adi Muljo.
Author: Muljo, Stefan Adi.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): NIH Director's Seminar Series The Integrative Immunobiology Section is interested in understanding how gene expression programs are orchestrated in our cells, particularly stem cells. Specifically, the laboratory studies how these systems are controlled by non-coding RNAs and RNA-binding proteins. Our major goal is to discover novel molecular circuits that control cell fates in the hematopoietic and immune systems, since perturbations in their genetic regulatory networks underlie many diseases. To address these fundamental issues, we employ an integrative systems biology approach to reverse engineer the molecular logic of cell fate determination. We combine genome- and transcriptome-wide measurements with experimental perturbations in order to test and refine our models. As one example of our success, we identified the RNA-binding protein Lin28b as a lineage-determining factor for fetal hematopoietic stem cells, a discovery with potentially important implications for Regenerative and Precision Medicine. At a basic level, we demonstrate the concept of post-transcriptional (re)programming of cell fate decisions.
Subjects: Embryonic Stem Cells
Gene Expression Regulation--genetics
RNA, Untranslated--genetics
RNA-Binding Proteins--genetics
Publication Types: Lectures
Webcasts
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NLM Classification: QU 475
NLM ID: 101697731
CIT Live ID: 20295
Permanent link: https://videocast.nih.gov/launch.asp?20025