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Novel concepts in radiation-induced normal tissue injury

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Air date: Friday, June 3, 2016, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 124, (66 Live, 58 On-demand)
Category: NIH Director's Seminars
Runtime: 00:55:24
Description: NIH Director's Seminar Series

Radiation therapy is delivered to over one half of all cancer patients. Efforts to enhance the efficacy of radiation have centered on technologic improvements in radiation delivery and leveraging a growing understanding of tumor radiobiology. Despite numerous recent advances in radiation delivery techniques, radiation exposure of normal tissues within the treatment volume can result in chronic injury, such as fibrosis and organ dysfunction. The study of radiation injury models has provided insight into the molecular events leading to radiation injury. Chronic oxidative stress after exposure of normal tissues to irradiation can result in progressive inflammation and fibrosis characterized by a predominance of macrophages. Irradiated organs, such as lung, exhibit a dose dependent senescence of resident stem cells, resulting in parenchymal depletion and organ dysfunction. Targeting senescence and associated changes in tissue after exposure to irradiation provides a unique opportunity to prevent and mitigate chronic injury from radiation.
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NLM Title: Novel concepts in radiation-induced normal tissue injury / Deborah E. Citrin.
Author: Citrin, D.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): Radiation therapy is delivered to over one half of all cancer patients. Efforts to enhance the efficacy of radiation have centered on technologic improvements in radiation delivery and leveraging a growing understanding of tumor radiobiology. Despite numerous recent advances in radiation delivery techniques, radiation exposure of normal tissues within the treatment volume can result in chronic injury, such as fibrosis and organ dysfunction. The study of radiation injury models has provided insight into the molecular events leading to radiation injury. Chronic oxidative stress after exposure of normal tissues to irradiation can result in progressive inflammation and fibrosis characterized by a predominance of macrophages. Irradiated organs, such as lung, exhibit a dose dependent senescence of resident stem cells, resulting in parenchymal depletion and organ dysfunction. Targeting senescence and associated changes in tissue after exposure to irradiation provides a unique opportunity to prevent and mitigate chronic injury from radiation.
Subjects: Radiation Injuries--prevention & control
Radiotherapy Dosage
Radiotherapy--adverse effects
Tissues--injuries
Tissues--radiation effects
Publication Types: Lectures
Webcasts
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Caption Text: Download Caption File
NLM Classification: WN 250
NLM ID: 101686946
CIT Live ID: 19263
Permanent link: https://videocast.nih.gov/launch.asp?19721