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Pursuing Health Disparities from the Neighborhood to the Bench: The View from Baltimore

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Air date: Friday, April 22, 2016, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 130, (70 Live, 60 On-demand)
Category: NIH Director's Seminars
Runtime: 01:01:55
Description: NIH Director's Seminar Series

Health disparities research is, by the nature of the problem, a discipline that requires interdisciplinary investigations that critically explore psychosocial, environmental, behavioral and biological factors to unravel the causes and develop the interventions that will lead to the elimination of differential health burdens and longevity status. At the forefront is investigation of the transduction factors that transform social determinates of health into disease and identification of the pivotal intersections where social and biologic factors ‘react’ to drive disparities. Health disparities research still has need of observational and longitudinal studies, as one of the factors that has driven these disparities has been the failure to consistently include minority and socioeconomically diverse research participants in clinical and basic science research studies. Our work focuses on examining various etiological factors that may drive health disparities by conducting observational epidemiologic studies but with special focus on understanding the underlying molecular and biological factors that may create a specific susceptibility or underlie dysfunctional interactions between the environment and the health of individuals over time. Our 3 main aims are: to examine the effects of race and socioeconomic status on the development of age-associated health disparities in an urban-dwelling, bi-racial socioeconomically diverse cohort, to evaluate the contribution of oxidative stress/oxidative DNA damage and inflammatory theory of aging in the development of health disparities and to identify the genetic and genomic factors that may be associated with age-associated health disparities. The talk will focus on selected findings from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study relevant to ongoing laboratory aims.
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NLM Title: Pursuing health disparities from the neighborhood to the bench : the view from Baltimore / Michele K. Evans.
Author: Evans, Michele K.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): NIH Director's Seminar Series Health disparities research is, by the nature of the problem, a discipline that requires interdisciplinary investigations that critically explore psychosocial, environmental, behavioral and biological factors to unravel the causes and develop the interventions that will lead to the elimination of differential health burdens and longevity status. At the forefront is investigation of the transduction factors that transform social determinates of health into disease and identification of the pivotal intersections where social and biologic factors "react" to drive disparities. Health disparities research still has need of observational and longitudinal studies, as one of the factors that has driven these disparities has been the failure to consistently include minority and socioeconomically diverse research participants in clinical and basic science research studies. Our work focuses on examining various etiological factors that may drive health disparities by conducting observational epidemiologic studies but with special focus on understanding the underlying molecular and biological factors that may create a specific susceptibility or underlie dysfunctional interactions between the environment and the health of individuals over time. Our 3 main aims are: to examine the effects of race and socioeconomic status on the development of age-associated health disparities in an urban-dwelling, bi-racial socioeconomically diverse cohort, to evaluate the contribution of oxidative stress/oxidative DNA damage and inflammatory theory of aging in the development of health disparities and to identify the genetic and genomic factors that may be associated with age-associated health disparities. The talk will focus on selected findings from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study relevant to ongoing laboratory aims.
Subjects: Baltimore
Health Status Disparities
Minority Groups
Socioeconomic Factors
Publication Types: Lectures
Webcasts
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NLM Classification: WA 300 AM3
NLM ID: 101682330
CIT Live ID: 18926
Permanent link: https://videocast.nih.gov/launch.asp?19641