NIH VideoCast - Nucleic Acid Detection in Host Defense and Autoimmunity

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Nucleic Acid Detection in Host Defense and Autoimmunity

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Air date:	Wednesday, April 13, 2016, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 324 (54 Live, 270 On-demand)
Category:	Immunology
Runtime:	00:54:31
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Immunology Interest Group Dan Stetson graduated from Duke University in 1997 and then received his Ph.D. in 2002 from the University of California, San Francisco, working in the lab of Richard Locksley. After completing postdoctoral work with Ruslan Medzhitov at Yale University, Dr. Stetson joined the University of Washington Department of Immunology in April 2008. Research in the Stetson lab focuses on mechanisms by which cells detect and respond to viral infection. All organisms have viral pathogens, and all organisms have sensors that detect foreign nucleic acids. In vertebrates, these sensors coordinate an inducible antiviral response by activating the production of type I interferons (IFNs). While the pleiotropic roles of IFNs have been studied since their discovery almost six decades ago, recent advances have allowed to understand their means of induction and complex regulation in molecular detail. The Stetson lab seeks to understand precisely how these pathways are activated, how they are regulated, the nature of the endogenous RNAs and DNAs that can trigger them, how they interact with each other, and how they are antagonized by viruses.

NLM Title:	Nucleic acid detection in host defense and autoimmunity / Daniel B. Stetson, Ph.D ; Immunology Interest Group.
Author:	National Institutes of Health (U.S.). Immunology Interest Group,
Publisher:
Abstract:	(CIT): Immunology Interest Group. Dan Stetson graduated from Duke University in 1997 and then received his Ph.D. in 2002 from the University of California, San Francisco, working in the lab of Richard Locksley. After completing postdoctoral work with Ruslan Medzhitov at Yale University, Dr. Stetson joined the University of Washington Department of Immunology in April 2008. Research in the Stetson lab focuses on mechanisms by which cells detect and respond to viral infection. All organisms have viral pathogens, and all organisms have sensors that detect foreign nucleic acids. In vertebrates, these sensors coordinate an inducible antiviral response by activating the production of type I interferons (IFNs). While the pleiotropic roles of IFNs have been studied since their discovery almost six decades ago, recent advances have allowed to understand their means of induction and complex regulation in molecular detail. The Stetson lab seeks to understand precisely how these pathways are activated, how they are regulated, the nature of the endogenous RNAs and DNAs that can trigger them, how they interact with each other, and how they are antagonized by viruses.
Subjects:	Autoimmune Diseases--immunology DNA, Viral Host-Pathogen Interactions--immunology RNA, Viral
Publication Types:	Lecture Webcast

NLM Classification:	QW 160
NLM ID:	101682322
CIT Live ID:	18886
Permanent link:	https://videocast.nih.gov/watch=18886

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