NIH VideoCast - Reproducible Research: Many Dimensions and Shared Responsibilities

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Reproducible Research: Many Dimensions and Shared Responsibilities

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Air date:	Monday, March 14, 2016, 2:30:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 388 (184 Live, 204 On-demand)
Category:	Special
Runtime:	01:58:49
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Biomedical researchers have an ethical responsibility to ensure the reproducibility and integrity of their work, so that precious research resources are not wasted and, most importantly, flawed or misleading results do not make their way to clinical studies where the faulty evidence could adversely affect study participants. Many factors have been suggested as contributors to irreproducible biomedical research, including poor study design, analytic instability of measurement methods, sloppy data handling, inappropriate and misleading statistical analysis methods, improper reporting or interpretation of results, and, on rare occasions, outright scientific misconduct. These problems can occur in any type of biomedical study, whether preclinical or clinical, large or small. Examples of the many potential pitfalls will be discussed along with suggested approaches to avoid them. The first half of the seminar will focus mainly on issues that arise commonly in preclinical and small clinical studies or studies performed retrospectively using stored biospecimens. The second half will elaborate on aspects that are particularly problematic in research involving the use of novel measurement technologies such as “omics assays” which generate large volumes of data and require specialized expertise and computational approaches for proper data analysis and interpretation. The discussions will emphasize the importance of including in a research team all individuals with the needed expertise as early as possible in a project in order to promote a sense of engagement and facilitate good communication across disciplines. Shared credit for scientific accomplishments should be understood as an acceptance of shared accountability for the integrity of the work. For more information go to https://datascience.nih.gov/reproducible_research_workshop

NLM Title:	Reproducible research : many dimensions and shared responsibilities / Lisa Meier McShane.
Author:	McShane, Lisa Meier. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): Biomedical researchers have an ethical responsibility to ensure the reproducibility and integrity of their work, so that precious research resources are not wasted and, most importantly, flawed or misleading results do not make their way to clinical studies where the faulty evidence could adversely affect study participants. Many factors have been suggested as contributors to irreproducible biomedical research, including poor study design, analytic instability of measurement methods, sloppy data handling, inappropriate and misleading statistical analysis methods, improper reporting or interpretation of results, and, on rare occasions, outright scientific misconduct. These problems can occur in any type of biomedical study, whether preclinical or clinical, large or small. Examples of the many potential pitfalls will be discussed along with suggested approaches to avoid them. The first half of the seminar will focus mainly on issues that arise commonly in preclinical and small clinical studies or studies performed retrospectively using stored biospecimens. The second half will elaborate on aspects that are particularly problematic in research involving the use of novel measurement technologies such as "omics assays" which generate large volumes of data and require specialized expertise and computational approaches for proper data analysis and interpretation. The discussions will emphasize the importance of including in a research team all individuals with the needed expertise as early as possible in a project in order to promote a sense of engagement and facilitate good communication across disciplines. Shared credit for scientific accomplishments should be understood as an acceptance of shared accountability for the integrity of the work.
Subjects:	Biomedical Research Reproducibility of Results
Publication Types:	Lecture Webcast

NLM Classification:	W 20.5
NLM ID:	101680584
CIT Live ID:	18656
Permanent link:	https://videocast.nih.gov/watch=18656

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